中英文介绍丨艾美捷Q-dextran（Q-葡聚糖）解决方案

Q-dextran is a polycationic derivative of dextran. These derivatives are distinct from DEAE-dextrans in that they only contain quaternary amine groups. Unlike DEAE-dextrans, Q-dextrans will be charged over a wide range of pH (pH 4-10). Q-dextrans will also have a much stronger net charge than corresponding DEAE-dextrans. All batches are checked for molecular weight, degree of substitution and loss on drying. TdB Labs produce Q-dextran from 4 kDa to 150 kDa. Q-dextrans are supplied as a white powder.

Structure

Q-dextrans are synthesised by reacting dextran fractions with 2,3-epoxypropyltrimethylammonium chloride. The nitrogen content is approximately 2% which corresponds to one quaternary ammonium group for every four glucose units.

Storage and stability

Q-dextran is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature.

Solubility

Q-dextran dissolves readily in water.

Application

Polycationic products exhibit a wide variety of effects in cellular systems and are of interest as adjuvants in vaccines. Q-dextran has a much stronger net charge than corresponding DEAE-dextrans and will thus give enhanced responses in systems where this effect is important.

艾美捷Q-dextran（Q-葡聚糖）#QD4、#QD10、#QD20等是葡聚糖的聚阳离子衍生物。这些衍生物与DEAE-葡聚糖的不同之处在于它们仅含有季胺基团。与DEAE-葡聚糖不同，Q-葡聚糖将在很宽的pH范围内（pH 4-10）充电。Q-葡聚糖的净电荷也将比相应的DEAE-葡聚糖强得多。检查所有批次的分子量、取代程度和干燥失重。TdB实验室生产4 kDa至150 kDa的Q-葡聚糖。Q-葡聚糖以白色粉末形式提供。

Q-dextran（Q-葡聚糖）为白色粗粉，易溶于水。氮含量约为 2%（通过元素分析），这对应于每四个葡萄糖单元大约一个季铵基团。含氮量为1.5 ~ 2.5%。与DEAE-葡聚糖不同，Q-葡聚糖将在宽pH范围内（pH 4-10）带电。它们还具有强得多的净电荷，因此在这种效应很重要的系统中给予增强的响应。聚阳离子产品在细胞系统中表现出广泛的作用，并且作为疫苗中的佐剂是令人感兴趣的。

Q-dextran（Q-葡聚糖）的应用：

聚阳离子产品在细胞系统中表现出多种作用，并作为疫苗中的佐剂而备受关注。Q-dextran（Q-葡聚糖）比相应的DEAE-葡聚糖具有更强的净电荷，因此在这种效应很重要的系统中将提供增强的响应。

Q-dextran（Q-葡聚糖）相关研究：

CM-葡聚糖

葡聚糖

赖氨酸葡聚糖

苯基葡聚糖

聚蔗糖

透明质酸

来源：https://www.amyjet.com/brand/blue-dextran.shtml